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Filtered Search Results
Medchemexpress LLC 4',7-Dimethoxyisoflavone | 1157-39-7 | 25 MG
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4',7-Dimethoxyisoflavone is isolated from the leaves of *Albizzia lebbeck* and demonstrates antifungal activity. In vitro studies indicate its effectiveness against various plant pathogenic fungi, with sensitivity varying among different fungal species.
- Purity: 98.20%
- Molecular weight: 282.29
- Formula: C17H14O4
- Appearance: Solid
- Color: White to off-white
- Structure classification: Flavonoids, isoflavones
- Initial source: Plants, Leguminosae, *Glycine max (L.) merr*
- Endogenous metabolite: Yes
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Medchemexpress LLC IL-31 Cynomolgus H 10ug | 10ug
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IL-31 is a multifunctional cytokine that activates STAT3 through IL-31 heterodimeric receptors (IL31RA and OSMR) and may activate STAT1 and STAT5 IL-31 is known for its involvement in skin immunity where it regulates immune responses IL-31 Protein Cynomolgus (HEK293 His) is the recombinant cynomolgus-derived IL-31 protein expressed by HEK293 with C-His labeled tag
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eMolecules 50289-13-9 | 4-hydroxyoxane-4-carboxylic acid | MFCD14602031 | 1g
Pharmablock | 4-hydroxyoxane-4-carboxylic acid | 1g | 551116364 | PBLJ2659 | 50289-13-9 | MFCD14602031 | 146.142 | C6H10O4
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eMolecules Building Block Tool
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Medchemexpress LLC Methyl 3,3-dimethoxypropionate | 7424-91-1 | MFCD00010650 | ≥98.0% | 148.16 g/mol | C6H12O4 | 1,000 G
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Methyl 3,3-dimethoxypropionate is a small organic ester used as a biochemical reagent and synthetic building block. It functions as a protected methyl ester derivative of 3-hydroxypropionic acid, suitable for use in organic synthesis and life-science research, and is supplied at high purity for laboratory applications.
- High purity suitable for research applications.
- Molecular weight 148.16 g/mol and formula C6H12O4.
- Useful as a protected ester intermediate in synthetic chemistry.
- Available in multiple packaging sizes for lab-scale use.
- Supplied for research use in laboratory environments.
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Medchemexpress LLC LM11A-31 dihydrochloride | 1243259-19-9 | 99.9% | 316.27 | 1 ML
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LM11A-31 dihydrochloride is a non-peptide modulator of p75NTR (neurotrophin receptor p75) and an orally active, potent antagonist of proNGF (nerve growth factor). This amino acid derivative demonstrates high blood-brain barrier permeability, effectively blocking p75-mediated cell death. It has been shown to reverse cholinergic neurite dystrophy in mouse models of Alzheimer's disease at mid- to late-stage progression.
- Non-peptide p75NTR modulator
- Orally active and potent proNGF antagonist
- Amino acid derivative
- High blood-brain barrier permeability
- Blocks p75-mediated cell death
- Reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models
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Medchemexpress LLC (S,R,S)-AHPC-amido-C5-acid | 2162120-87-6 | >99.5% | 25 MG
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(S,R,S)-AHPC-amido-C5-acid is a laboratory chemical identified by CAS number 2162120-87-6. It is supplied as a solid and exhibits chemical stability under recommended storage conditions, making it suitable for various research applications.
- Stable under recommended storage conditions.
- Solid appearance.
- Suitable for laboratory chemical applications.
- Recommended storage at -20°C, sealed, away from moisture and light.
- Shipping at room temperature if less than two weeks.
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Apexbio Technology LLC Ro 31-8220 125314-64-9 50mg
Ro 31-8220 (CAS 125314-64-9) is a potent and selective inhibitor of protein kinase C (PKC) targeting isoforms PKC- (IC50 5 nM) PKC- I (24 nM) PKC- II (14 nM) PKC- (27 nM) and PKC- (24 nM) PKC is a Ca2 and phospholipid-dependent serine/threonine kinase involved in signaling pathways regulating cell proliferation and malignancy Ro 31-8220 modulates downstream signaling by inducing c-Jun expression and activating JNK1 while inhibiting MKP-1 and c-Fos expression independent of PKC activity In immunological studies it suppresses IL-2 production (IC50 80 nM) T cell proliferation (IC50 350 nM) and CD25 expression indicating inhibition of both early and late T cell activation Ro 31-8220 is widely utilized in cellular and molecular studies to dissect PKC-dependent and independent signaling mechanisms
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Medchemexpress LLC PI3K-IN-31 | 1359956-12-9 | 99.3% | C19H23F2N7O3 | 25 MG
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PI3K-IN-31 (Compound 6b) is a potent PI3K inhibitor, demonstrating significant activity against various PI3K isoforms including PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ. This compound has been noted for its anticancer properties.
- Potent PI3K inhibitor
- Exhibits anticancer effects
- Inhibits PI3Kα with an IC50 of 3.7 nM
- Inhibits PI3Kβ with an IC50 of 74 nM
- Inhibits PI3Kγ with an IC50 of 14.6 nM
- Inhibits PI3Kδ with an IC50 of 9.9 nM
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Medchemexpress LLC 2-Octyl-4(1H)-quinolone | 80554-60-5 | >=98.0% | 257.37 | 50 MG
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2-Octyl-4(1H)-quinolone is a quinolinone alkaloid that can be isolated from *Ruta graveolens*. It is intended for research use only. It has shown antiproliferative activity against human A2780 cells with an IC50 of 12 μM after 2 days by Alamar blue assay. The compound is a solid, white to off-white in color, with the formula C17H23NO. It is classified under Alkaloids and Other Alkaloids, and its initial source is from the plants Rutaceae, specifically *Ruta graveolens Linn.*.
- Quinolone alkaloid.
- Isolated from *Ruta graveolens*.
- For research use only.
- Exhibits antiproliferative activity against human A2780 cells with an IC50 of 12 μM after 2 days by Alamar blue assay.
- Solid, white to off-white in color.
- Chemical formula C17H23NO.
- Classified under alkaloids.
- Sourced from Rutaceae, *Ruta graveolens Linn.*.
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Medchemexpress LLC 7,4'-Dihydroxyflavone | 2196-14-7 | 25 MG
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7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid isolated from Glycyrrhiza uralensis. It functions as an eotaxin/CCL11 inhibitor and a CBR1 inhibitor with an IC50 of 0.28 μM. This compound suppresses eotaxin production and prevents dexamethasone (Dex)-paradoxical adverse effects. Furthermore, 7,4'-DHF inhibits MUC5AC gene expression, mucus production, and secretion by regulating NF-κB, STAT6, and HDAC2, decreasing PMA-stimulated MUC5AC expression in NCI-H292 human airway epithelial cells with an IC50 of 1.4 μM.
- Purity: 99.64%
- Molecular weight: 254.24
- Formula: C15H10O4
- CAS number: 2196-14-7
- Appearance: Solid, light yellow to yellow
- Structure classification: Flavonoids, Flavones, Phenols, Polyphenols
- Acts as eotaxin/CCL11 and CBR1 inhibitor (IC50: 0.28 μM)
- Inhibits MUC5AC gene expression and mucus production
- IC50: 1.4 μM (NCI-H292 human airway epithelial cell)
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TARGETMOL CHEMICALS INC LOC14 25MG
Also available in 5 mg 10 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. LOC14 to be the most potent PDI inhibitor reported to date( EC50 500 nM)purity: 98%
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Medchemexpress LLC 1-cyclobutyl-3-(2,6-dimethylphenyl)-7-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-3,4-dihydropy | 2172617-15-9 | 99.8% | 50MG
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1-cyclobutyl-3-(2,6-dimethylphenyl)-7-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-3,4-dihydropy | 2172617-15-9 | 99.8% | 50MG
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Medchemexpress LLC SRI 6409-94 | 127697-58-9 | 99.25% | 379.49 | 5 MG
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SRI 6409-94 is an orally active Ro 13-6298 analogue that is teratogenic. It serves as a molecular tool to study the effect of the three-dimensional configuration of retinol on teratogenic activity.
- Orally active compound.
- Aids in the study of retinol's three-dimensional configuration and its effect on teratogenic activity.
- Induces deformed offspring in a dose-dependent manner in virgin female outbred Syrian golden hamsters.
- Leads to significant reductions in mean fetal body weight and the number of ossified skeletal districts in studies.
- Purity of 99.25%.
- Available in solid form with a light yellow to brown color.
- Stable for 3 years at -20°C as a powder, and 2 years at 4°C as a powder.
- In solvent, stable for 6 months at -80°C and 1 month at -20°C.
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Medchemexpress LLC 31-Norlanostenol | 16910-39-7 | 1 MG
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31-Norlanostenol is a triterpenic compound isolated from the latex of Euphorbia officinarum. It can act as an efficient insect growth regulator on S. frugiperda and Tenebrio molitor. This product is for research use only.
- Triterpenic compound
- Isolated from the latex of Euphorbia officinarum
- Acts as an efficient insect growth regulator on S. frugiperda and Tenebrio molitor
- Purity: 99.94%
- Molecular Weight: 414.71
- Formula: C29H50O
- Appearance: Solid
- Color: White to off-white
- Structure classification: Terpenoids, Triterpenes
- Initial source: Plants, Euphorbiaceae, Euphorbia boetica
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Medchemexpress LLC Leb-03-146 | 2858812-91-4 | 98.1% | C46H57N11O8 | 1 MG
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LEB-03-146 is a deubiquitinase-targeting chimera (DUBTAC) that links AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 via a PEG2 linker. This compound is intended for research use only.
- Demonstrates significant WEE1 stabilization in HEP3B hepatoma cancer cells.
- Functions as a deubiquitinase-targeting chimera (DUBTAC).
- Links AZD1775 (Adavosertib) to the OTUB1 recruiter EN523.
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